Connectivity-wise, an audio interface is an audio interface. They come with connections in the form of pci card, USB, firewire, and now thunderbolt. (I've seen a couple HDMI connecting models now too. They all look exceptionally cheap and feature only unbalanced outputs. Maybe still worth considering on a low budget. HDMI would be the bigger concern though. There's so much copy protection gone wild stuff going on with HDMI that it's just best to avoid it if you can. Your just going to end up getting into it arguing/demanding refunds on crippled products.)
Like any hardware connected to a computer, you need to have a driver installed. Most of the USB interfaces are what's called "class compliant" on the Mac (OSX), meaning they use a standard built-in driver included with stock OSX. The firewire/thunderbolt/pci versions usually need a driver install. Windows needs a driver install for everything as a rule. Most audio interfaces make a Windows version of their driver nowadays. Linux is starting to be embraced. It looks like professional audio will be moving to Linux as Apple dies.
Sound Blasticator is the ratty cheap end of things. You know how some of us are making claims that devices like modern AD and DA converters and mic preamps have risen to a level of quality that the differences aren't night and day anymore? Products like Sound Blasticator just might be a data point to refute that!
Someone mentioned Logitech speakers (hopefully in jest!)
Possible the worst speakers made save for any soundbar. Their gimmick was to trick people into thinking they needed a different kind of speaker for their computer. "Computer speakers". There's really no such thing. You can buy speakers with amps built in (powered monitors) all day long and they range from cheap to high end just like passive speakers. "Computer speaker" is a grifter term.