The only universal remote I've ever had was an older Logitech 1000:
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It was generous gift from wife. I spent about 2 weeks trying to make peace with it & it's been in the box ever since. I'm just not a macro kind of guy. The home screen said something like "what do you want to do?" and gave suggestions like watch TV , listen radio, etc. It seemed not to be able (or I couldn't figure it out) that I had LD, DVD & Blu-ray players & was no good for controlling my quad decoders & wouldn't let me adjust F/B or L/R balance on my Anthem. The factory remote did.
I'm not dissing Logitech remotes as others here hav had good success. And my son in law has a newer remote like Gene's & quite likes. However his set up is much simpler than mine.
What Learned from this experience is that you have to actually use & work with a uni remote to know if it does what you want. Also it probably will not fulfill all the options you can get on multiple dedicated remotes.
Good luck. I hope you find the remote of your dreams!